SOFTWARE TOOLS FOR DRUG DEVELOPMENT

ALLOMETRICA

Allometric scaling for prediction of clinical PK parameters from preclinical data.

CYCLO4

Modelling of the mammalian cell cycle and cell cycle checkpoints, signal transduction and apoptosis.

DPDMODEL

Use of differential pharmacodynamics to predict in vivo activity from in vitro data and optimise the design of in vivo combination studies.

GRECFIT

Analysis of drug combination data and quantitation of synergism and antagonism by the method of Greco.

PDMODEL

Pharmacokinetic/pharmacodynamic modelling of biomarker data.

TIGHTFIT

Nonlinear regression analysis of enzyme inhibition data by the tight-binding inhibition equation of Morrison.

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